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Oleg Sapozhnikov

Senior Principal Engineer

Email

olegs@apl.washington.edu

Phone

206-543-1385

Videos

Characterizing Medical Ultrasound Sources and Fields

For every medical ultrasound transducer it's important to characterize the field it creates, whether for safety of imaging or efficacy of therapy. CIMU researchers measure a 2D acoustic pressure distribution in the beam emanating from the source transducer and then reconstruct mathematically the exact field on the surface of the transducer and in the entire 3D space.

11 Sep 2017

Mechanical Tissue Ablation with Focused Ultrasound

An experimental noninvasive surgery method uses nonlinear ultrasound pulses to liquefy tissue at remote target sites within a small focal region without damaging intervening tissues.

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23 Mar 2017

Boiling histotripsy utilizes sequences of millisecond-duration HIFU pulses with high-amplitude shocks that form at the focus by nonlinear propagation effects. Due to strong attenuation of the ultrasound energy at the shocks, these nonlinear waves rapidly heat tissue and generate millimeter-sized boiling bubbles at the focus within each pulse. Then the further interaction of subsequent shocks with the vapor cavity causes tissue disintegration into subcellular debris through the acoustic atomization mechanism.

The method was proposed at APL-UW in collaboration with Moscow State University (Russia) and now is being evaluated for various clinical applications. It has particular promise because of its important clinical advantages: the treatment of tissue volumes can be accelerated while sparing adjacent structures and not injuring intervening tissues; it generates precisely controlled mechanical lesions with sharp margins; the method can be implemented in existing clinical systems; and it can be used with real-time ultrasound imaging for targeting, guidance, and evaluation of outcomes. In addition, compared to thermal ablation, BH may lead to faster resorption of the liquefied lesion contents.

Burst Wave Lithotripsy: An Experimental Method to Fragment Kidney Stones

CIMU researchers are investigating a noninvasive method to fragment kidney stones using ultrasound pulses rather than shock waves. Consecutive acoustic cycles accumulate and concentrate energy within the stone. The technique can be 'tuned' to create small fragments, potentially improving the success rate of lithotripsy procedures.

20 Nov 2014

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Publications

2000-present and while at APL-UW

Modeling of the acoustic radiation force in elastography

Prieur, F., and O.A. Sapozhnikov, "Modeling of the acoustic radiation force in elastography," J. Acoust. Soc. Am., 142, 947-961, doi:10.1121/1.4998585, 2017.

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1 Aug 2017

Elastography is a non-invasive imaging technique that can assess in vivo tissue stiffness. In shear wave elastography imaging, the acoustic radiation force (ARF) produced by focused ultrasound generates a local force that produces shear waves. The authors compare three existing formulations for the ARF: its full expression in the second-order approximation and two simplified formulations using a quasi-plane wave and an attenuated plane wave approximation. Analytical expressions for the ARF are derived for the special cases of a concave spherical source and a quasi-Gaussian beam. They provide expressions for the resulting ARF and show discrepancies between the different formulations. For strongly divergent or highly focused beams the ARF expressed by the second-order approximation significantly differs from both simplified formulations. However, despite those differences the second-order and quasi-plane wave approximations create identical shear displacements in tissue. To compute the ARF and the displacements produced by a conventional ultrasound probe, the three formulations were incorporated into the k-Wave simulation package. The second-order and quasi-plane wave approximations give different forces but nearly identical displacements while the plane wave approximation significantly differs. It is concluded that to properly take into account the ultrasound field structure, the second-order or quasi-plane wave approximations should be preferably used.

Shock formation and nonlinear saturation effects in the ultrasound field of a diagnostic curvilinear probe

Karzova, M.M., P.V. Yuldashev, O.A. Sapozhnikov, V.A. Khokhlova, B.W. Cunitz, W. Kreider, and M.R. Bailey, "Shock formation and nonlinear saturation effects in the ultrasound field of a diagnostic curvilinear probe," J. Acoust. Soc. Am., 141, 2327-2337, doi:10.1121/1.4979261, 2017.

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1 Apr 2017

Newer imaging and therapeutic ultrasound technologies may benefit from in situ pressure levels higher than conventional diagnostic ultrasound. One example is the recently developed use of ultrasonic radiation force to move kidney stones and residual fragments out of the urinary collecting system. A commercial diagnostic 2.3 MHz C5-2 array probe has been used to deliver the acoustic pushing pulses. The probe is a curvilinear array comprising 128 elements equally spaced along a convex cylindrical surface. The effectiveness of the treatment can be increased by using higher transducer output to provide a stronger pushing force; however nonlinear acoustic saturation can be a limiting factor. In this work nonlinear propagation effects were analyzed for the C5-2 transducer using a combined measurement and modeling approach. Simulations were based on the three-dimensional Westervelt equation with the boundary condition set to match low power measurements of the acoustic pressure field. Nonlinear focal waveforms simulated for different numbers of operating elements of the array at several output power levels were compared to fiber-optic hydrophone measurements and were found to be in good agreement. It was shown that saturation effects do limit the acoustic pressure in the focal region of a diagnostic imaging probe.

Design of HIFU transducers for generating specified nonlinear ultrasound fields

Rosnitskiy, P.B., P.V. Yuldashev, O.A. Sapozhnikov, A.D. Maxwell, W. Greider, M.R. Bailey, and V.A. Khokhlova, "Design of HIFU transducers for generating specified nonlinear ultrasound fields," IEEE Trans. Ultrason., Ferroelect., Freq. Control, 64, 374-390, doi:10.1109/TUFFC.2016.2619913, 2017.

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1 Feb 2017

Various clinical applications of high-intensity focused ultrasound have different requirements for the pressure levels and degree of nonlinear waveform distortion at the focus. The goal of this paper is to determine transducer design parameters that produce either a specified shock amplitude in the focal waveform or specified peak pressures while still maintaining quasi-linear conditions at the focus. Multiparametric nonlinear modeling based on the Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation with an equivalent source boundary condition was employed. Peak pressures, shock amplitudes at the focus, and corresponding source outputs were determined for different transducer geometries and levels of nonlinear distortion. The results are presented in terms of the parameters of an equivalent single-element spherically shaped transducer. The accuracy of the method and its applicability to cases of strongly focused transducers were validated by comparing the KZK modeling data with measurements and nonlinear full diffraction simulations for a single-element source and arrays with 7 and 256 elements. The results provide look-up data for evaluating nonlinear distortions at the focus of existing therapeutic systems as well as for guiding the design of new transducers that generate specified nonlinear fields.

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Inventions

Systems, Devices, and Methods for Separating, Concentrating, and/or Differentiating Between Cells from a Cell Sample

Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.

Patent Number: 9,645,080

Tom Matula, Andrew Brayman, Oleg Sapozhnikov, Brian MacConaghy, Jarred Swalwell, Camilo Perez

Patent

9 May 2017

Portable Acoustic Holography Systems for Therapeutic Ultrasound Sources and Associated Devices and Methods

Patent Number: 9,588,491

Oleg Sapozhnikov, Mike Bailey, Vera Khokhlova, Wayne Kreider

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Patent

7 Mar 2017

The present technology relates generally to portable acoustic holography systems for therapeutic ultrasound sources, and associated devices and methods. In some embodiments, a method of characterizing an ultrasound source by acoustic holography includes the use of a transducer geometry characteristic, a transducer operation characteristic, and a holography system measurement characteristic. A control computer can be instructed to determine holography measurement parameters. Based on the holography measurement parameters, the method can include scanning a target surface to obtain a hologram. Waveform measurements at a plurality of points on the target surface can be captured. Finally, the method can include processing the measurements to reconstruct at least one characteristic of the ultrasound source.

Methods of Soft Tissue Emulsification using a Mechanism of Ultrasonic Atomization Inside Gas or Vapor Cavities and Associated Systems and Devices

Patent Number: 9,498,651

Oleg Sapozhnikov, Mike Bailey, Larry Crum, Vera Khokhlova, Yak-Nam Wang

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Patent

22 Nov 2016

The present technology is directed to methods of soft tissue emulsification using a mechanism of ultrasonic atomization inside gas or vapor cavities, and associated systems and devices. In several embodiments, for example, a method of non-invasively treating tissue includes pulsing ultrasound energy from the ultrasound source toward the target site in tissue. The ultrasound source is configured to emit high intensity focused ultrasound (HIFU) waves. The target site comprises a pressure-release interface of a gas or vapor cavity located within the tissue. The method continues by generating shock waves in the tissue to induce a lesion in the tissue at the target site. The method additionally includes characterizing the lesion based on a degree of at least one of a mechanical or thermal ablation of the tissue.

More Inventions

Acoustics Air-Sea Interaction & Remote Sensing Center for Environmental & Information Systems Center for Industrial & Medical Ultrasound Electronic & Photonic Systems Ocean Engineering Ocean Physics Polar Science Center
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